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FIGURE 1 In the context of critical illness, the etiology of anemia is frequently multifactorial

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Similar to protein thiols (cysteines), GSH can be subject to one-electron oxidation by ROS such as superoxide anion (O 2 • − ), which mediates derivatives with an unpaired electron, including the thiyl radical (glutathionyl radical [GS•]) and the thiyl peroxyl radical (GSOO•)