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In terms of substrate profile, the m6A modification catalyzed by METTL3 has a broad RNA-type specificity, covering classical RNA molecules such as mRNAs, tRNAs and ribosomal RNA (rRNA)s, as well as regulatory RNAs, such as miRNA precursors and long-stranded non-coding RNAs (lncRNAs) (30)

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A decrease of 0.1 pH units may not seem like much, but because the pH scale is logarithmic, each unit on the pH scale represents a tenfold change in acidity

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