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Among the great variety of CPPs, penetratin was reported to be effective in the nose-to-brain delivery of antidiabetic peptides, including insulin and exendin-4, in an animal model of AD (Table 3)

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The combination of methylcobalamin and folinic acid induced increases of 15% in total glutathione and 20% in reduced glutathione, respectively (28), while NAC treatment has demonstrated a 60% increase from baseline (24)