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Key findings relevant to patients with both conditions include: • SURPASS-2 (NEJM, 2021): tirzepatide 15 mg produced a mean HbA1c reduction of 2.46% vs 1.86% for semaglutide 1 mg (Ozempic) — a statistically significant superior glycaemic effect alongside greater weight loss • SURPASS-3 (Lancet, 2021): tirzepatide outperformed insulin degludec on both HbA1c reduction and weight loss in people with type 2 diabetes inadequately controlled on other agents — with participants on tirzepatide 15 mg losing 11.9 kg vs a gain of 2.3 kg on insulin • SURPASS-4 (Lancet, 2021): in patients with type 2 diabetes and high cardiovascular risk, tirzepatide produced superior glycaemic control and weight loss vs insulin glargine, with no increase in cardiovascular events • SURPASS-CVOT (ongoing): a dedicated cardiovascular outcomes trial for tirzepatide in type 2 diabetes
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