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6 Perspective: The intersecting burdens of HBV infection, alcohol use, and liver cancer While the oncogenic mechanisms of HBV, including viral DNA integration, chronic liver inflammation, and HBV protein-driven signaling, are well characterized, growing evidence highlights alcohol consumption as a potent and often underrecognized cofactor linked to disease progression

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5 However, it’s important to note that serum levels do not accurately reflect B12 cellular sufficiency