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The main reasons that have been put forward to explain the lack of success in trials with motilin agonist drugs for gastroparesis have been the use of too high doses, which impact on gastric accommodation, and the use of long-acting agents which are prone to desensitization (62, 103)

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🔹 KPV (Lysine–Proline–Valine) KPV is a tripeptide fragment derived from alpha-MSH (melanocyte-stimulating hormone)