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Low- to moderate-intensity exercise induces a controlled increase in ROS, which activates Nrf2 without causing significant cellular damage [163]

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The study primarily utilized HCT116 MTAP − / − (MTAP-deficient) and HCT116 WT (wild-type) cells, as well as various tumor-derived and gene-knockout cell lines like HAP1 FANCI − , HAP1 FANCD2 − , and HAP1 FANCL − , to examine the impact of MR on cancer cells (79)