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Alleviation of cadmium toxicity in Zea mays L. through up-regulation of growth, antioxidant defense system and organic osmolytes under calcium supplementation | PLOS One

It was not a major reason for discontinuation in the trial, but it represents a side effect category that tirzepatide users do not encounter

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This is sometimes called a Herxheimer reaction or a "healing crisis." During this phase, you might feel a temporary dip in energy, a slight headache, or a general sense of malaise as your system clears out the "trash." This usually passes within a few days of consistent use