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In HeLa lines, AKT-siRNA enhanced glucose uptake and HK2 expression, suggesting that inhibition of AKT may increase glucose uptake by detaching HK2 from the mitochondria (Neary and Pastorino 2013)

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Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh