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This encompasses interferon-gamma (IFN-γ), which facilitates a Th1-mediated inflammatory response, and interleukin-4 (IL-4), which endorses Th2 cell development

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[0667] In some embodiments, the pharmacological chaperone binds to ?- glucocerebrosidase (acid ?-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, or GCase)