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Curcumin is the key active component of turmeric, showing antioxidant, anti-inflammatory, anti-cancer, anti-microbial, and tissue (heart, nerve, liver) protective effects ( Curcumin (50–200 mg/kg) was found to upregulate MMP-1 and inhibit TIMP-1, resulting in a reduction in liver granuloma volume by up to 79% and collagen content by 38.6% ( S

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Based on the above, the simplest way to prevent OS related to DE is consuming calorie-restricted healthy meals that are filled with micronutrients and vitamins capable of promoting microbiota diversity, working as ROS scavengers and antioxidants, and limiting the extension of OS in the LFU and in the entire body (Figure 3)