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While some studies show a weak correlation between bacterioplankton community structure and metabolic function due to functional redundancy 18,19 , other studies have revealed that different bacterioplankton taxa exploit DOM resources along a continuum of varying quantity, quality and lability 20,21,22

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This article aims to systematically review the main characteristics and dynamic evolution of the intervertebral disc microenvironment under physiological and pathological conditions, focusing on analyzing the impact of the degenerative microenvironment on the biological behavior of exogenous MSCs and endogenous progenitor cells