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Clinically, HD is characterized by a triad of motor, cognitive, and psychiatric manifestations that reflect the progressive disruption of cortico-striato-thalamo-cortical circuits including the motor, associative, and limbic loops [17]

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Given that H 2 O 2 is bio-membrane permeable, it indicated that excess H 2 O 2 , when present in the colonocyte , could easily diffuse through the colonocyte cell membrane into the lamina propria, where blood vessels reside