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The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis | medRxiv

In addition, the basal ganglia targeting efficiency and blood–brain barrier penetration of ferroptosis inhibitors (such as Fer-1) have not been evaluated, and long-term safety data in HD patients are lacking, including whether treatment disturbs iron metabolism in unaffected brain regions and causes cognitive side effects

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