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The primary histological endpoint of the month 18 interim analysis (intent-to-treat [ITT], n=931) was improvement in fibrosis ≥1 stage with no worsening of NASH using the NASH Clinical Research Network criteria

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The 2.5 mg dose is better called the low-dose starter, because it is the labeled start and now has short direct non-diabetic data behind it.¹⁸ Microdosing has been used for tolerability testing, metabolic-marker support, step-down protocols, and maintenance, not for proven long-term obesity outcomes