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Along these lines it is interesting that elevated expression of mammalian 14-3-3θ can promote alpha synuclein extrusion 63 , akin to our finding that 14-3-3 protein FTT-2 is required for efficient exophergenesis and can drive enhanced exopher production when over-expressed in C

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It accumulates at high concentrations under hypoxic conditions, inducing A2AR to impair the function and proliferation of T and NK cells, while also stimulating the expression of Foxp3 in Treg cells, leading to immune evasion in cancer and resulting in adverse clinical outcomes (187)