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However, under pathological conditions, such as in T2DM, the BBB is compromised, leading to the abnormal activation of AGE and the receptor for AGE (RAGE) interaction, setting off a self-perpetuating cascade (83)

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Similarly, the simultaneous interaction of quercetin and carnosine with the HES-1 protein was demonstrated, with a binding energy of -5.2 kcal/mol (Fig