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A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

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(2008) highlighted the following mechanisms by which plant-derived compounds manifest their anti-diabetic properties: Inhibition of renal glucose reabsorption Reduction of the activity of carbohydrate enzymes (α-amylase with β-galactosidase and α-glucosidase) Reduction of dietary blood sugar (which stimulates hepatic glycolysis and glycogenesis) Inhibition of potassium channel flow The mechanisms of plant polyphenolic components against T2D involve the stimulation of cAMP that increases exocytosis in β-cells, inhibition of insulin degradative processes, prevention of oxidative stress, regeneration of β-cells, reparation and cellular hypertrophy, and cellular proliferation in the islets of Langerhans [6, 74, 97-101]