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The 2019 paper by Fang and colleagues in Journal of Neuroinflammation and the 2022 paper by Zheng and colleagues in Molecular Neurobiology both demonstrate that TREK-1 deficiency in mouse models of stroke and intracerebral hemorrhage worsens outcomes — suggesting that chronic, broad TREK-1 blockade could plausibly be harmful in individuals with compromised cerebrovascular status, even if it produces behavioral benefit in healthy rodents

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10.1016/j.archoralbio.2019.104584 210 ZhaoC.SunJ.FangC.TangF

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