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Mitochondrial damage occurs in the early stages of PD and a large body of evidence indicates that the activity of mitochondrial complex ∣ was impaired in tissues after the death of PD, and another typical feature of PD was that GSH is selectively depleted from the (Liddell and White, 2018)

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Disclosures: Akiko Sugiyama: Nothing to Disclose, Susan Hagen: Nothing to Disclose, David Cohen: Nothing to Disclose 1036 REDUCED BACTEROIDES THETAIOTAOMICRON CONTRIBUTES TO THE DISORDERED METABOLISM OF BILE ACIDS IN MASLD PATIENTS Jian Wu 1 Chang Liu 1 Yu-Li Wang 1 Li Zhang 1 Li Xie 1 Yong-Yu Yang 1 Ning-Ping Zhang 2 Jia Ding 3 Yang Wu 1 , 1 Fudan University Shanghai Medical College, 2 Zhongshan Hospital of Fudan University, 3 Shanghai Jing’an District Central Hospital Background: Bile acid metabolism is often disturbed in metabolic dysfunction-associated steatotic liver disease (MASLD) along with gut dysbiosis