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In people with vitamin B12 deficiency, symptoms may include fatigue, lack of energy, dizziness, shortness of breath, irregular or fast heartbeat, pale or yellowish skin, numbness or tingling in the hands and feet, smooth or tender tongue, decreased appetite, weight loss, diarrhea, muscle weakness, unsteadiness, trouble walking, mental confusion, forgetfulness, irritability, and personality changes

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It takes about two weeks for vaccines to become fully effective after a shot