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Two (5.9%) DPYD carriers who received a standard fluoropyrimidine dose and 12 (1.6%) wild-type patients also treated with a standard dose had severe neutropenia (RR 3.69, 95% CI 0.53–16.97) in the study by Lunenburg et al, 7 whereas six (35.3%) DPYD carriers and 38 (6.5%) wild-type patients had severe neutropenia (RR 5.43, 95% CI 2.15–11.53) in the study by Toffoli et al

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