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Stabilized PINK1 recruits and activates cytosolic Parkin, which ubiquitinates multiple OMM proteins, forming polyubiquitin chains that serve as signals for autophagy receptors, including sequestosome 1 (SQSTM1/p62), optineurin (OPTN), NBR1, TAX1BP1, and NDP52/CALCOCO2 [83, 92]