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The TYR gene, involved in melanin biosynthesis in melanocytes, has been significantly associated with vitiligo in the European population.63 The roles of many susceptibility loci remain unknown, highlighting the lack of understanding in the etiopathogenesis of vitiligo, which continues to be a challenge today
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therefore, it is more plausible that an effective vascular improvement is reached in mildβmoderate vasculogenic ED patients, specifically mediated by l-ARG supplementation, as demonstrated by the evidence of PSV values compatible with absence of ED in a subset of mildβmoderate vasculogenic ED patients at study completion