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For example, age-associated increases in DNA damage activates NAD+-dependent PARP1, 63,64 and although PARP1 is a critical DNA repair enzyme, its persistent activation is harmful due to this contribution to NAD+ depletion

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Different yields of recombinant PPO mutants have been described before for c g AUS1 51 and dandelion PPO ( To PPO-2 and To PPO-6) 52 indicating that mutations influence the expression yield of recombinant PPOs