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Item - Schematic representation of the γ-glutamyl cycle. - Public Library of Science - Figshare

Another approach is to rationally design nanozymes that mimic the active sites of hydrolases, isomerases, or lyases by incorporating functional groups or cofactors

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Mammals possess five HK isozymes, namely HK1, HK2, HK3, glucokinase (GCK), and hexokinase domain-containing 1 (HKDC1), with HK2 being the most extensively studied in glycolysis ( Figure 1 )