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The early reports of relapse or exacerbation of neural symptoms in pernicious anemia patients treated with folic acid describe dose levels ranging from 20 to 50 mg/d (7–12)

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Moreover, in a bite-opening (BO) mouse model, allopurinol administered at 50 mg/kg/day for 2 weeks ameliorated BO-induced cardiac dysfunction, counteracting increased XO-mediated ROS, suppressing calmodulin kinase II activation, and normalizing phosphorylation of ryanodine receptor 2 and phospholamban [188]