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Age at dementia onset represents a critical modifier of seizure risk (Mendez et al., 1994

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We will survey five biological markers of psychosis (hypothalamic-pituitary-adrenal-axis (HPA-axis) hyperactivity, dopamine dysfunction, reduced oxytocin, neuroinflamation and oxidative stress) and how they may interact with developmental adversity to influence both childhood and adolescent neurodevelopmental disturbances associated with the illness