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Ototoxic interaction between noise and pheomelanin: distortion product otoacoustic emissions after acoustical trauma in chloroquine-treated red, black, and albino guinea pigs

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Altogether, these data suggest that the Akt/GSK3β and NF-κB pathways are involved both in the regulation of CBS activity (as assessed by the decreased H 2 S production 24 h after treatment), but also in the regulation of CBS expression, effect which is observed at the mRNA level 24 h after treatment and at the protein level 48 h after treatment