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Reported side effects include nasal cavity discoloration in approximately 10% of intranasal users (per the Alzheimer's Drug Discovery Foundation summary), increased blood glucose in people with diabetes, overstimulation or anxiety in sensitive users, nasal irritation with frequent intranasal use, and sleep disruption with late-day administration

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While we proposed not to nominate these codes as potentially misvalued, we requested public comments and recommendations, including those from the RUC, to better understand these codes, particularly regarding typical direct PE inputs and work values