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If you do not have severe neurological symptoms, however, research suggests that very high-dose oral supplementation (typically 1,000 mcg daily) can effectively treat B-12 deficiency — even in people who have compromised absorption due to lack intrinsic factor (a cause of "pernicious anemia") or from gastrointestinal disease or bowel resection (Lacombe, Am J Clin Nutr 2024

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