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The inner (oxidized) sulfur of thiosulfate is converted to sulfite (SO 3 2− or H 2 SO 3 ), presumably by either a glutathione (GSH)-dependent thiosulfate reductase (reaction 9) or a thiosulfate sulfurtransferase (reaction 10)

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Quantification of apoptotic cells revealed that there was a significant reduction in CGN apoptosis with Immunocal pretreatment compared to CGNs treated with CuCl 2 alone (Figure 3(b))