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Semaglutide is contraindicated in the following conditions: Thyroid Cancer or MEN 2: If you or a family member has ever had a thyroid tumor, particularly medullary thyroid carcinoma (MTC) or a neuroendocrine tumor such as Multiple Endocrine Neoplasia type 2 (MEN 2) syndrome, semaglutide is contraindicated for you

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Some people respond quickly (within weeks) and others may take a full 4 months before they respond favorably to the therapeutic methylfolate dosing