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Blood glutathione status. Levels of GSH (A) and GSSG (B), ratios of GSH... | Download Scientific Diagram

In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig

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The drug 5-FU was administrated daily at a dose of 30 mg/kg intraperitoneally, while normal saline was used as a control