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Key pathways such as PI3K/AKT/mTOR (PAM), RAS/RAF/MEK/ERK [22], and Notch are frequently activated in GBM, promoting cell proliferation, survival, and invasion, while also contributing to the resistance of GBM cells to chemotherapy and radiation therapy

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The uneven distribution of RNA-seq reads across the locus, peaking in the middle of the annotated gene model, further suggest the current annotation is inaccurate and the locus produces two distinct transcripts (Supplementary Fig

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