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Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter

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That GPCRs exhibit constitutive activity in the absence of any agonist has been proposed to explain why certain ligands, originally thought to be antagonists, may act to inhibit basal activity of unoccupied receptors (i.e., they are inverse agonists) (Costa and Cotecchia, 2005)