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Over the 16-week treatment period, the decline in ALS Functional Rating Scale–Revised (ALSFRS-R) scores was smaller in the MeCbl group than in the placebo group, and adverse event rates were similar between groups.6 6.2 Peripheral Neuropathy and Axonal Degeneration A phase I/II open-label trial evaluated 14 patients with chronic immune-mediated or hereditary neuropathies and electrodiagnostic evidence of axonal degeneration

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Researchers have also identified mechanisms of ferroptosis that do not depend on GPX4, and a major component of this GPX4-independent pathway is ferroptosis suppressor protein 1 (FSP1) (24)