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These exercise-related cognitive and synaptic effects may be linked to AMPK, PGC-1α, fibronectin type III domain containing 5 and BDNF-related pathways, as well as reductions in hippocampal BACE and APP expression (129,130)

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B12’s vital role in the methylation cycle explains why the vitamin has an effect on areas as diverse as the nervous system, DNA synthesis, detoxification and the synthesis of hormones and neurotransmitters