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Interestingly, removal of ovarian hormones did result in increased weight gain over the course of HFD-feeding, and an increase in whole body adiposity, accompanied by worsened glucose tolerance and insulin resistance, indicating that these hormones likely play a more important role in classical white adipose tissue expansion and glucose homeostasis, rather than in ECM remodelling in PVAT

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These advancements would significantly enhance the clinical applicability of exosomes, paving the way for innovative solutions in the treatment of endometrial fibrosis and other fibrotic diseases