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However, common limitations also existed, including the potential for recall bias, timing of exposure relative to the introduction of aspartame into the food supply, reliance on food composition databases that may not reflect product reformulations and composition changes for aspartame, and the potential for non-differential exposure misclassification.] Tamez et al

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In vitiligo patients’ skin, activated innate immune cells (e.g., DCs and NK cells) secrete multiple pro-inflammatory cytokines and chemokines, including IL-1β, IL-6, IFN-γ, TNF-α, CXCL10, and CCL2 (94, 95)