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The end goal would be to continue refining the PBPK model with these additional clinical, as well as mechanistic in vitro, data to accurately simulate various real-world scenarios (e.g., different object drugs, kratom doses, kratom consumption patterns, special populations)

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The transdermal composition of any of the preceding claims wherein polymer is polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)