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A similar BODIPY 165 was synthesized by Popov and Plenio in 2022 [205] via nucleophilic substitution of meso -chloroine in BODIPY with imidazole during the synthesis of a series of BODIPY-based photosensitisers (Scheme 86)

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The proposed mechanisms center on angiogenesis (new blood vessel formation), modulation of growth factor and nitric oxide pathways, and effects on collagen organization during healing