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The original articles investigating the biological activities of main OOPs were identified using the following search keywords: hydroxytyrosol OR tyrosol OR oleuropein OR oleocanthal OR oleacein OR olive oil phenols AND antioxidant OR anti-inflammatory OR cardioprotective OR neuroprotective OR osteoprotective OR anticancer OR antidiabetic OR antiobesity OR antimicrobial OR metabolism OR bioavailability covering the 2010–2019 time span