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In Vitro Metabolic Stability: Preclinical Pharmacology Core - UT Southwestern, Dallas, Texas

Sources “The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis” Journal of Personalized Medicine (2021) “Vit B12 supplement of 500 μg/d for eight weeks does not normalize urinary methyl-malonic acid or other biomarkers of vitamin B12 status in elderly people” J Nutr

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Nonetheless, B vitamin concentrations in the low-but-still-normal range may go undetected in routine clinical practice because they are unlikely to produce overt symptoms and are not typically measured in the absence of clinical indicators of vitamin insufficiency