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Consistently, histopathological analyses of gastrointestinal biopsies from patients treated with taxanes revealed characteristic microscopic features, including an accumulation of crypt cells in mitotic arrest and the formation of abnormal “ring mitoses”, providing direct evidence of drug effects on the epithelial cells (51)

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Additionally, miR-31 has been identified as a direct inhibitor of the upstream STAT1 transcription factor, which downregulates T-bet, consequently inhibiting the production of IFN-γ and the activation of CD4 + T cells, thus serving a protective function during HIV infection (85)