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This is consistent with ISS capturing systemic tumor burden, whereas ADO production is shaped by niche-specific microenvironmental factors that vary substantially between patients

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Among the processes triggered by neutrophils in COVID-19, NETs are released having neutrophil elastase (NE) as one of the leading members of their networks, a proteolytic enzyme stored in azurophilic granules, secreted to degrade proteins (Middleton et al., 2020)