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Item - Schematic representation of the γ-glutamyl cycle. - Public Library of Science - Figshare

The mechanical stress generated by BTNPs creates temporary pores in the cell membrane, allowing more chemotherapeutic drugs to enter, thereby enhancing cytotoxic effects

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Risk factors for grade-3/4 toxicities and delay in MTX elimination Predictors with a significant difference in the univariate analysis or identified clinically were added in the binary logistic regression model