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In addition, non-pharmacological interventions for gout, including dietary modifications, weight management, and physical therapies, demonstrate multi-target efficacy by reducing serum uric acid levels, modulating inflammatory pathways, and improving metabolic parameters, thereby decreasing flare frequency, preventing complications, and complementing pharmacotherapy in mild-to-moderate cases

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AOD-9604 development was ultimately discontinued in 2007 when the effect size was deemed insufficient for a standalone obesity drug