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Although the difference between the NMN and placebo intervention groups was not statistically significant in the 6-min walking endurance test, it was evident that the NMN intervention group showed sustained improvement in walking endurance from 30 to 60 d of treatment [146]

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Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig