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A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma

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Consistent with this, an imbalance between ROS and the antioxidant systems has been linked to the development of severe disease [21], mainly mediated by the release of pro-inflammatory cytokines [22], leading to the vascular dysfunction characteristic of severe DENV infection [23]